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Traduzione in italiano e testo originale delle diverse versioni del celebre e bellissimo Passare la vita nel peccato e nella infelicità (1) In questa versione, la più nota, la storia è raccontata al maschile, come nelle versioni di ad Est, come quella illustrata sotto) e il nome, in definitiva, potrebbe essere del tutto casuale.

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Llego tarde a la cita. Lo scienziato stra Lo spettacolo maraviglioso. Il Teatro della Pergola: l'opera a Firenze. To support this proposition, they report on the current experience at the Rocinha slum in Rio de Janeiro, where a community health center was built by the neighborhood association 12 years ago and has been managed by the community since then. The hospital referral rate at the clinic, requests for laboratory tests, and use of precriptions have been considerably limited, although these services are available. These low rates are attributed to the possibility of.

The changes observed on the rules of retirement point out the increasing of the elderly's stay on the market. This stay will only be viable if there are also changes at the work stations, making them more flexible and compatible with the characteristics of a population that ages. Ergonomic analysis point out some directions of researches that can contribute to the improvement of work conditions: confections of technical and organizational provisions based on the analysis of the work how it's truly done and a politics of continuous formation that allows workers to stay actives on the actual context of technological innovations.

The majority of research about tobacco use in China focuses on Han Chinese, the main ethnic group comprising over 90 per cent of the population, and a paucity of research exists on ethnic minorities. The present study elucidates tobacco use among the Dai people, an ethnic group in Yunnan Province, Southwest China.

The study design consisted of interviews and grounded theory methodology in a symbolic interactionist theoretical framework. The categories of the grounded theory revealed tobacco consumption was weaved in a complex web of meanings: social practices, perceptions of health, and work lives as agriculturalists, situated in Dai cultural and social milieu. An important finding was the stage-managing of tobacco as a symbol of 'tradition' versus 'modernity': Through a process of contested modernity, the older men championed long-standing tobacco customs as representative of Dai heritage and thus their own tobacco use as upholding traditions amid encroaching cultural and societal change in China.

These findings are important because little is known about Dai people's tobacco use and how they are responding to social change. There are also implications for the development of culturally-appropriate tobacco control strategies. Dai -Kou type conjugate gradient methods with a line search only using gradient.

In this paper, the Dai -Kou type conjugate gradient methods are developed to solve the optimality condition of an unconstrained optimization, they only utilize gradient information and have broader application scope. Under suitable conditions, the developed methods are globally convergent. Qing Dai attenuates nonsteroidal anti-inflammatory drug-induced mitochondrial reactive oxygen species in gastrointestinal epithelial cells. Treatments with nonsteroidal anti-inflammatory drugs NSAIDs have increased the number of patients with gastrointestinal complications.

Qing Dai has been traditionally used in Chinese herbal medicine for various inflammatory diseases such as ulcerative colitis. We previously reported that Qing Dai suppressed inflammations by scavenging reactive oxygen species ROS in ulcerative colitis patients. In this study, we aimed to elucidate whether Qing Dai decreased mitochondrial ROS production in NSAID-treated gastrointestinal cells by examining cellular injury, mitochondrial membrane potentials, and ROS production with specific fluorescent indicators.

Treatments with indomethacin and aspirin induced cellular injury and mitochondrial impairment in the gastrointestinal cells. Under these conditions, mitochondrial alterations were observed on electron microscopy. Qing Dai prevented these complications by suppressing ROS production in gastrointestinal cells. The objective of this work was to characterize the requirement priorities for workplace design of agricultural tractors of the national market, as per standards of ergonomics and safety.

The patterns were composed by agricultural new tractors rubber tires, with minimum gauge of 1, mm, without any alterations in their original characteristics on the part of the manufacturer or reselling, in commercialization in national territory, related to the internal disposition of the operation commands, to the seats and to the accesses of the workplaces. As comparative analysis of the customer requirements for of these machines and, consequently, the hierarchization of the necessary requirements for the project of workplaces. Expression of DAI by an oncolytic vaccinia virus boosts the immunogenicity of the virus and enhances antitumor immunity.

Full Text Available In oncolytic virotherapy, the ability of the virus to activate the immune system is a key attribute with regard to long-term antitumor effects. Vaccinia viruses bear one of the strongest oncolytic activities among all oncolytic viruses.


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However, its capacity for stimulation of antitumor immunity is not optimal, mainly due to its immunosuppressive nature. To overcome this problem, we developed an oncolytic VV that expresses intracellular pattern recognition receptor DNA-dependent activator of IFN-regulatory factors DAI to boost the innate immune system and to activate adaptive immune cells in the tumor. We showed that infection with DAI -expressing VV increases expression of several genes related to important immunological pathways. Treatment with DAI -armed VV resulted in significant reduction in the size of syngeneic melanoma tumors in mice.

When the mice were rechallenged with the same tumor, DAI -VV-treated mice completely rejected growth of the new tumor, which indicates immunity established against the tumor. We also showed enhanced control of growth of human melanoma tumors and elevated levels of human T-cells in DAI -VV-treated mice humanized with human peripheral blood mononuclear cells. We conclude that expression of DAI by an oncolytic VV is a promising way to amplify the vaccine potency of an oncolytic vaccinia virus to trigger the innate—and eventually the long-lasting adaptive immunity against cancer.

Evaluation of re-criticality potential in Fukushima Dai -ichi reactors following core damage accidents. The re-criticality potential of the debris-bed, formed of the degraded core materials, cannot be ruled out during the cooling-down procedure of the Fukushima Dai -ichi NPPs. The results obtained for the re-criticality potential, characterized by the eigen-values k-eff dependent on the debris composition formed at the core, RPV bottom, and PCV pedestal, are reflected to the arguments on the re-criticality prevention measures, such as timing and concentration of boron-compounds, during the cooling-down process of the Fukushima Dai -ichi NPPs.

Analysis of prescription database extracted from standard textbooks of traditional Dai medicine.

In a group of experts produced a set of seven Dai medical textbooks on this subject. The first two were selected as the main data source to analyse well recognized prescriptions. Objective To quantify patterns of prescriptions, common ingredients, indications and usages of TDM. Methods A relational database linking the prescriptions, ingredients, herb names, indications, and usages was set up.

Frequency of pattern of combination and common ingredients were tabulated. Results A total of prescriptions and herbs were compiled. Prescriptions based on "wind" disorders, a detoxification theory that most commonly deals with symptoms of digestive system diseases, accounted for over one third of all prescriptions. The major methods of preparations mostly used roots and whole herbs. Conclusion The information extracted from the relational database may be useful for understanding symptomatic treatments. Antidote and detoxification theory deserves further research.

To quantify patterns of prescriptions, common ingredients, indications and usages of TDM. A relational database linking the prescriptions, ingredients, herb names, indications, and usages was set up. A total of prescriptions and herbs were compiled. The information extracted from the relational database may be useful for understanding symptomatic treatments.

We tested our hypotheses that 1 pretreatment with DKT would block the colorectal distention-induced visceromotor response in rats, and 2 pretreatment with DKT would attenuate colorectal distention-induced adrenocorticotropic hormone ACTH release and anxiety-related behavior. The objective of the project is to develop a pre-operative system based on EO data and ground measurements integration to support the volcanic risk monitoring of the Italian Civil Protection Department which requirements and need are well integrated in the GMES Emergency Core Services program.

The project philosophy is to implement, by incremental versions, specific modules which allow to process, store and visualize through Web GIS tools EO derived parameters considering three activity phases: 1 knowledge and prevention; 2 crisis; 3 post crisis. In order to combine effectively the EO data and the ground networks measurements the system will implement a multi-parametric analysis tool, which represents and unique tool to analyze contemporaneously a large data set of data in "near real time".

Transazioni "professionali" in valuta estera, rischio di cambio e crescita del sistema bancario internazionale. The movement from fixed to floating exchange rates led to predictions that foreign exchange markets might become more volatile. In particular, the issue whether speculation in the market was stabilising or destabilising was widely debated.

Concern was also expressed whether sufficient speculative funds would be available to ensure capital mobility. The author argues that the development of international banking has allowed banks to undertake more speculative foreign exchange trading without incurring greater risk, thus alleviating the problem of capital mobility. In one county of Southwest China bordering Myanmar, large numbers of minority Dai women leave to work in southern Thailand. Many are married and they leave behind husbands and children, sending remittances and returning home intermittently.

These men become second husbands just as the Dai women become second wives. This paper examines the complicated set of HIV risks and assumptions that emerge from the circular Dai exodus to Thailand and the manner in which transnational employment networks impact on domestic and sexual relationships for women and their non-migrant husbands back home. Efficiency of herbal medicine Dai -kenchu-to on portal blood flow in rat models. Report by the 'Fukushima Dai -Ichi major accident' nuclear subgroup. This report comprises a description of the succession of events in the Fukushima- Dai -Ichi power plant, a discussion of the situation of the nuclear industry and energy in France after this accident French nuclear stock, security organisation , and a discussion on the fuel cycle and on future opportunities comparison with EPR - Gen II safety measures, perspectives beyond the EPR.

Numerous appendices are proposed, made of documents from different bodies involved in nuclear industry, energy and safety. They deal with the Fukushima accident, with light water and pressurized water reactors, with severe accidents in PWRs, and so on. Fukushima- Dai -Ichi accident. Information bulletin no. This news bulletin has been prepared by the French institute of radiation protection and nuclear safety IRSN for the information of French residents in Japan.

It presents, first, the situation at the date of the bulletin of the radioactive contamination in the provinces close to the Fukushima Dai -ichi damaged site, the follow-up of the commercialisation restrictions of some food products vegetables, mushrooms, milk. Then, it gives some general recommendations to residents concerning good food consumption practices and supplies a list of particularly impacted areas where it is to be highly avoided to travel to.

It presents, first, the situation at the date of the bulletin of the food chain contamination in the provinces close to the Fukushima Dai -ichi damaged site, the particular case of rice contamination monitoring and the controls performed at retailer shops. Then, it gives some general recommendations to residents concerning good food consumption and hygiene practices and recommends to avoid any unnecessary travel to the most impacted areas close to the prohibited access area.

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Situation of Fukushima Dai -ichi power plant in Japan - June 1, status. This situation note is established according to the information gained on June 1, by the crisis centre of the French institute of radiation protection and nuclear safety IRSN. The situation of the cores of reactors 1, 2 and 3 of the Fukushima I site Dai -ichi and of the different spent fuel pools is briefly presented as well as the actions in progress for the control of environmental radioactive releases and for the progressive recovery of the facilities control. Situation of Fukushima Dai -ichi power plant in Japan - May 25, status.

This situation note is established according to the information gained on May 25, by the crisis centre of the French institute of radiation protection and nuclear safety IRSN. Evaluation of seismic design by students made after Fukushima Dai -ichi accident. The sense of anxiety for safety of nuclear power plants among people in Japan has not disappeared after Fukushima Dai -ichi accident because of a typical country with frequent earthquakes.

The provision of information for seismic design in nuclear power plants prepared for easier comprehension is always required in any kind of study meetings for the social acceptance of nuclear power plants. In the present paper, the effect of the provision of information made an attempt for students in Hokkaido University is reported. Colitis with wall thickening and edematous changes during oral administration of the powdered form of Qing- dai in patients with ulcerative colitis: a report of two cases.

Orally administered Qing- dai , called indigo naturalis in Latin, is reportedly useful for the treatment of ulcerative colitis. We herein describe two patients with ulcerative colitis who developed colitis with wall thickening and edematous changes during oral administration of the powdered form of Qing- dai. In Case 1, a year-old man developed colitis similar to ischemic colitis with bloody stool that recurred each time he ingested Qing- dai. He had no signs of recurrence upon withdrawal of Qing- dai. Edema and congestion but no ulceration were present in the mucosa of the resected specimen.

Both patients exhibited abdominal pain with bloody diarrhea, and abdominal computed tomography showed marked wall edema affecting an extensive portion of the large bowel. The herbal medicine Dai -Kenchu-To directly stimulates colonic motility. Dai -kenchu-to DKT has attracted attention as a drug that improves the symptoms of postoperative ileus. However, the detailed mechanism of its action still remains unknown. The effect of DKT on colonic motility was herein evaluated using an original method.

Eight healthy male volunteers who understood the purpose of this study were enrolled. Dai -kenchu-to 5 g was dissolved in saline and administered into the cecum using a colonoscope until the ascending colon became distended. Colonic motility was observed by extrasomatic ultrasonography for 30 min. Colonic contractions were observed Every segment in the right colon divided by the crescentic folds contracted independently.

On the other hand, no colonic contractions were observed in the right colon after saline solution alone was administered to the ascending colon. In conclusion, DKT stimulates colonic motility immediately after administration, in the same manner as it does for the upper alimentary tract. Full Text Available The Fukushima Dai -Ichi accident in has affected various aspects of the nuclear society worldwide.

The accident revealed some problems in the conventional approaches used to ensure the safety of nuclear installations. To prevent such disastrous accidents in the future, we have to learn from them and improve the conventional approaches in a more systematic manner. In this paper, we will cover three issues. The first is to identify the key issues that affected the progress of the Fukushima Dai -Ichi accident greatly.

We examine the accident from a defense-in-depth point of view to identify such issues. The second is to develop a more systematic approach to enhance the safety of nuclear installations. We reexamine nuclear safety from a risk point of view. We use the concepts of residual and unknown risks in classifying the risk space. All possible accident scenarios types are reviewed to clarify the characteristics of the identified issues.

An approach is proposed to improve our conventional approaches used to ensure nuclear safety including the design of safety features and the safety assessments from a risk point of view.

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The Fukushima Dai -Ichi accident in has affected various aspects of the nuclear society worldwide. Population-based assessment of visual impairment among ethnic Dai adults in a rural community in China. Dai ethnicity is one of the major Chinese ethnic minorities with a population of about 1. We aimed to determine the prevalence and potential causes of visual impairment VI among ethnic Dai adults aged 50 years or older in a rural community in China. A population-based survey including ethnic Dai people The detailed eye examination was performed after pupil dilation by trained study ophthalmologists and optometrists.

The overall prevalence of presenting blindness and low vision was 3. The prevalence estimates were reduced to 2. Men were more likely to be affected by low vision but less likely to be blind compared with women. Cataract accounted for Intraduodenal and intrajejunal administration of the herbal medicine, dai -kenchu-tou, stimulates small intestinal motility via cholinergic receptors in conscious dogs. The aim of the present study was to study the effect and mechanism of action of intraduodenal and intrajejunal dai -kenchu-to, an herbal medicine clinically effective for uncomplicated postoperative adhesive intestinal obstruction, on upper gastrointestinal motility.

Five mongrel dogs were equipped with four strain-gauge force transducers on the antrum, duodenum, and proximal and distal jejunum to measure contractile activity. Dai -kenchu-to 0. The effect of atropine, hexamethonium, phentolamine, propranolol, and ondansetron on intraduodenal and intrajejunal dai -kenchu-to-induced contractions was studied. Plasma motilin was measured by specific radioimmunoassay.

Intraduodenal and intrajejunal dai -kenchu-to induced phasic contractions in the duodenum and proximal jejunum, respectively, and those contractions migrated distally. Phasic contractions induced by intraduodenal and intrajejunal dai -kenchu-to were inhibited by atropine and hexamethonium at all sites. Plasma motilin was not affected by dai -kenchu-to. Intraduodenal and intrajejunal dai -kenchu-to stimulates upper gastrointestinal motility at and distal to the administration sites through cholinergic receptors.

Misura e valutazione del rischio da esposizione al rumore per orchestrali di un teatro lirico nazionale - Measurement and risk assessment of noise exposure for orchestra members of an Italian opera house. Full Text Available Ad oggi in Letteratura sono presenti pochi studi di settore basati sulla valutazione del rischio rumore nei teatri lirici. This condition has come about in spite of the Italian Leg. Decree n. This paper reports the preliminary results of a pilot study of occupational exposure to noise of the symphony orchestra musicians of an Italian opera.

Surveys were carried out on a representative sample of members of the orchestra, using personal dosimeters and frequency analyzers. Sound recordings were made during the musical performances in the orchestra pit of the theater during the various types of theatrical performances. Aerial radiation monitoring around the Fukushima Dai -ichi Nuclear Power Plant using an unmanned helicopter. All rights reserved. The Fukushima Dai -ichi Accident and its implications for the safety of nuclear power. Five years ago the dramatic events in Fukushima that followed the massive earthquake and subsequent tsunami that struck Japan on March 11, sharpened the focus of scientists, engineers and general public on the broad range of technical, environmental and societal issues involved in assuring the safety of the world's nuclear power complex.

They also called into question the potential of nuclear power to provide a growing, sustainable resource of CO2-free energy. The issues raised by Fukushima Dai -ichi have provoked urgent concern, not only because of the potential harm that could result from severe accidents or from intentional damage to nuclear reactors or to facilities involved in the nuclear fuel cycle, but also because of the extensive economic impact of those accidents and of the measures taken to avoid them. An update on radioactive release and exposures after the Fukushima Dai -ichi nuclear disaster.

On 11 March , the Richter scale 0. Compounding this tragic loss of life, a series of equipment and structural failures at the Fukushima Dai -ichi nuclear power plant FDNP resulted in the release of many volatile radioisotopes into the atmosphere. In this update, we detail currently available evidence about the nature of immediate radioactive exposure to FDNP workers and the general population. We contrast the nature of the radioactive exposure at FDNP with that which occurred at the Chernobyl power plant 25 years previously.

Prediction of the exact health effects related to the FDNP release is difficult at present and this disaster provides the scientific community with a challenge to help those involved and to continue research that will improve our understanding of the potential complications of radionuclide fallout.

Outline and lessons learned. The severe accident that broke out at Fukushima Dai -ichi nuclear power stations on March 11, , caused seemingly infinite damage to the daily life of residents. Serious and wide-spread contamination of the environment occurred due to radioactive materials discharged from nuclear power stations NPSs. At the same time, many issues were highlighted concerning countermeasures to severe nuclear accidents. The accident is outlined, and lessons learned are extracted with respect to the safety of NPSs, as well as radiation protection of residents under the emergency involving the accident.

The materials of the current paper are those released by governmental agencies, academic societies, interim reports of committees under the government, and others. The system is being used in the Fukushima health management survey. The doses can be obtained by superimposing the behavior data of the residents on the dose rate maps. For grasping the doses, 18 evacuation patterns of the residents were assumed by considering the actual evacuation information before using the survey data. The doses of the residents from the deliberate evacuation area were relatively higher than those from the area within 20 km radius.

The estimated doses varied from around 1 to 6 mSv for the residents evacuated from the representative places in the deliberate evacuation area. The maximum dose in 18 evacuation patterns was estimated to be 19 mSv. Radioactive emissions into the atmosphere from the damaged reactors of the Fukushima Dai -ichi nuclear power plant NPP started on March 12th, Among the various radionuclides released, iodine I and cesium isotopes Cs and Cs were transported across the Pacific toward the North After the Chernobyl accident, only a few measurements of the gaseous I fraction were conducted compared to the number of measurements for the particulate It can be pointed out that during the Fukushima event, the Cs to Cs ratio proved to be different from that observed after the Chernobyl Nuclear accidents at the Fukushima Dai -ichi power plant.

History, events and consequences. Written few weeks after the accident, this article first recalls the circumstances earthquake and tsunami , and then describes the accidental process within the primary vessels of the Fukushima Dai -ichi number 1, 2 and 3 reactors. The author then describes the interventions which aimed at cooling these three reactors, the problem faced for the storage of used fuels, and then the sequence of accidents: loss of cooling means leading to an explosion, problems faced in the different storage pools. He describes the various steps of recovery primary cooling, electricity supply , discusses the consequences in terms of radioactivity releases in the plant environment with a comparison with Chernobyl, and also in terms of nature and quantity of radioactive elements.

He comments radioactivity controls and measurements, evacuation measures, measurements performed by the IAEA, measurements of sea radioactivity, and the establishment of maps of ground radioactivity around the plant. He discusses the perspectives associated with these measurements for the surroundings of the Fukushima site. How did Fukushima- Dai -ichi core meltdown change the probability of nuclear accidents? How to predict the probability of a nuclear accident using past observations?

What increase in probability the Fukushima Dai -ichi event does entail? Many models and approaches can be used to answer these questions. Poisson regression as well as Bayesian updating are good candidates. However, they fail to address these issues properly because the independence assumption in which they are based on is violated. We find an increase in the risk of a core meltdown accident for the next year in the world by a factor of ten owing to the new major accident that took place in Japan in NARAC provided a wide range of products and analyses as part of its support including: 1 Daily Japanese weather forecasts and hypothetical release generic source term dispersion predictions to provide situational awareness and inform planning for U.

The DOE Nuclear Incident Team NIT coordinated response activities, while DOE personnel provided predictive modeling, air and ground monitoring, sample collection, laboratory analysis, and data assessment and interpretation. Limited awareness of animal influenza prevention and control among Dai Lue smallholder farmers in Southwest China. Awareness of animal influenza and its prevention and control is important for ensuring livestock health, production and welfare.

In China, a country stereotyped as a major source of emerging zoonotic infectious diseases, research on the public understanding of animal influenza is limited to the Han, the main ethnic group. The present qualitative study in Southwest China investigated awareness of animal influenza among the Dai , an ethnic minority. The participants 15 men and 10 women, ages were smallholder farmers of pigs and poultry in rural areas of Jinghong, Xishuangbanna, Yunnan Province.

A mixture of interviews and group discussions took place in homes and villages. The participants were asked about their knowledge of avian influenza H7N9 , swine influenza H1N1 , precautions taken to protect against influenza, procedures when animals were sick and perceived risk of animal influenza. The data were analysed following coding and thematic analysis.

The findings demonstrated a limited understanding of animal health and welfare among participants. Specifically, they were largely unaware of animal influenza H7N9, H1N1 including its causes, symptoms, prevention and treatment.

The farmers were also uninformed of the risks they faced and unknowingly engaged in behaviours which increased direct or indirect exposure to infected animals, a risk factor for human infection. They also reported poor usage of veterinary services. In order to guarantee the health, welfare and production of their livestock, immediate action is needed to enable Dai smallholder farmers to prevent and respond to animal influenza effectively and timely.

Sugiyama, G. Kumekawa, H. The accident at Fukushima Dai -ichi Nuclear Power Station caused by the Great East Japan Earthquake and tsunami in March had a major impact on the safeguards situation at the site. From the day of the earthquake, JSGO and the IAEA have shared information on decommissioning activities and discussed how to deal with this difficult issue.

In May , the Fukushima Task Force was established. Its objective is to develop a holistic approach to safeguards implementation measures for the site, to monitor the re-establishment of safeguards, to facilitate discussion of relevant issues, and to consider possible approaches to longer-term safeguards challenges. All the fuels in spent fuel ponds in Units 5 and 6 and Common Spent Fuel Storage have been successfully re-verified.

Re-verification of fuels kept in spent fuel pond in Unit 4 is underway. Based on extensive information exchange, proactive discussions on safeguards approaches are being held for near-term issues. The damaged core material in Units will pose extreme difficulties in longer-term. A special sub-group has been established under the task force to address the issues. Although lessons learned from past nuclear accidents resulting in damage of core material have some relevance, none of them can be directly applicable for Fukushima.

Thus a foresighted and creative approach is needed. Close coordination with the IAEA and support from technically competent institutions in Japan and from abroad, such as DOE, are also essential to tackle the issues. Chinese herbal medicine Qing- Dai also known as indigo naturalis has been used to treat various inflammatory conditions. However, not much has been studied about the use of oral Qing- Dai in the treatment for ulcerative colitis UC patients. Studies exploring alternative treatments for UC are of considerable interest. In this study, we aimed at prospectively evaluating the safety and efficacy of Qing- Dai for UC patients.

The open-label, prospective pilot study was conducted at Keio University Hospital. A total of 20 patients with moderate UC activity were enrolled. Oral Qing- Dai in capsule form was taken twice a day daily dose, 2 g for 8 weeks. The clinical and endoscopic scores, CRP levels, and fecal occult blood results were also significantly improved. We observed 2 patients with mild liver dysfunction; 1 patient discontinued due to infectious colitis and 1 patient discontinued due to mild nausea.

This is the first prospective study indicating that oral Qing- Dai is effective for inducing remission in patients with moderate UC activity and can be tolerated. Thus, Qing- Dai may be considered an alternative treatment for patients, although further investigation is warranted. Karger AG, Basel. Although the Kampo medicine Dai -kenchu-to is widely used in Japan for treatment of postoperative ASBO, rigorous clinical studies for its use have not been performed. In the present retrospective observational study using the Japanese diagnosis procedure combination inpatient database, we selected propensity-score-matched patients with early postoperative ASBO following colorectal cancer surgery, who received long-tube decompression LTD with or without Dai -kenchu-to administration.

The success rates of LTD were not significantly different between Dai -kenchu-to users and nonusers In conclusion, the present study suggests that Dai -kenchu-to is effective for reducing the duration of LTD and saving costs. Efficacy of n-3 polyunsaturated fatty acids and feasibility of optimizing preventive strategies in patients at high cardiovascular risk: rationale, design and baseline characteristics of the Rischio and Prevenzione study, a large randomised trial in general practice. Full Text Available Abstract Background The optimization of preventive strategies in patients at high risk of cardiovascular events and the evaluation of bottlenecks and limitations of transferring current guidelines to the real world of clinical practice are important limiting steps to cardiovascular prevention.

Treatment with n-3 polyunsaturated fatty acids improves prognosis after myocardial infarction, but evidence of this benefit is lacking in patients at high cardiovascular risk, but without a history of myocardial infarction. Patients were randomly allocated to treatment with n-3 polyunsaturated fatty acids 1 g daily or placebo in a double-blind study and followed up for five years by their GPs to assess the efficacy of the treatment in preventing cardiovascular mortality including sudden death and hospitalization for cardiovascular reasons.

The secondary, epidemiological, aim of the study is to assess whether it is feasible to adopt current guidelines in everyday clinical practice, with a view to optimizing all the available preventive strategies in people at high cardiovascular risk. A nation-wide network of GPs admitted 12, patients to the study between February and March In critiquing maternal knowledge as feminist discourse, the women's strategies contribute theoretically to an integrative construction of care by reclaiming displaced knowledge discourses and diversity in meaning production.

Pragmatically, consciousness-raising collectives comprising the mothers and dais can cocreate narratives of our ways of maternal experiences articulated in public discourse to sustain equitability of knowledge traditions in migrant urban Third World contexts. In this presentation author analyse course of accident on Fukushima Dai -chi NPPs as well as consequences of this disaster. The following parts are presented: 1 Occurrence of the accident; 2 Evacuation of the residential people; 3 Deterioration and protraction of the accident; 4 Impact on society; 5 Situation of decontamination; 6 Long-term steps towards decommissioning; 7 Situation of other nuclear power stations; 8 Conclusions and lessons learned.

The accident is outlined, and lessons learned are extracted with respect to the safety o Introduction of new terms and lessons for radiological protection after Fukushima Dai -Ichi accident. The nuclear accidents in the world are very few among various types of operating facilities. However when an accident happened, we have learnt a lot to improve the philosophy, term, definitions, document preparation, equipment's requirement, supporting systems, awareness program and restriction etc.

After Fukushima Dai -ichi we have learnt a lot, in this view this paper has been prepared to discuss for radiological protection aspects. Recent Fukushima Dai -ichi accident in Japan was managed in appreciable manner but still new definitions and lessons for radiological protection have been emerged out.

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The present paper discusses difficulties w. The earthquake and tsunami on March 11, severely damaged the Fukushima Dai -ichi nuclear plant leading to the most severe nuclear incident since Chernobyl. Ongoing operations to cool the damaged reactors at the site have led to the generation of highly radioactive coolant water. This is currently mainly treated to remove Cs and Cs and passed through a reverse osmosis RO unit to reduce the salinity before being cycled back to the reactors. Because only the Cs isotopes are removed, the RO reject water still contains many radioactive isotopes and this has led to the accumulation of over , cubic meters 52 million gallons of extremely contaminated water which is currently stored on site in tanks.

EnergySolutions, in partnership with Toshiba, were contracted to develop a system to reduce 62 isotopes in this waste down to allowable levels. This was a significant technical challenge given the high background salt content of the wastewater, the variation in aqueous chemistry of the radioactive isotopes and the presence of non-active competing ions e. Ca and Mg which inhibit the removal of isotopes such as Sr and Sr Extensive testing was performed to design a suitable system that could meet the required decontamination goals.

These tests were performed over a 6 month period at facilities available in the nearby Fukushima Dai -ni laboratory using actual waste samples. The stored tank waste is fed into a preliminary precipitation system where iron flocculation is performed to remove a number of isotopes, including Sb, Ru, Mn and Co The supernatant is then fed into a second precipitation tank where the pH is adjusted and the bulk of the Mg, Ca and Sr precipitated out as carbonates and hydroxides.

After passing through a. Mental health problems after the Fukushima Dai -ichi nuclear power plant accident. The name of Fukushima has now become well-known worldwide after Hiroshima and Nagasaki as the third place exposed to radiation in Japan. This radiation pollution has severely damaged the chief industries of Fukushima Prefecture, namely agriculture, fishery, and tourist industry.

It has also stimulated strong anxious feelings among parents with young children. The accident has caused a critical situation in the psychiatric and mental health services in Fukushima as well. Five hospitals with psychiatric beds within 30 km from the Fukushima Dai -ichi Nuclear Power Plant were ordered to transfer their inpatients to other hospitals outside the designated 30 km-areas and to close down the hospitals immediately after the nuclear plant accident. In total, more than psychiatric beds disappeared in an instant, and 1, persons including psychiatric inpatients and residents of elderly people nursing homes were transferred to other facilities far away.

Rational explanation that low-level radiation in Fukushima will not do harm to people did not necessarily relieve existing anxiety among people. The terms 'safety' and 'relief' are usually used in combination; however, 'relief' was separated from 'safety' this time in Fukushima. People gradually began to feel 'relieved', when they themselves got involved in the cleaning work of radiation although its effect remained ambiguous. Now we have the following mental health problems after the Fukushima Dai -ichi nuclear power plant accident; recovery and maintenance of treatment systems for psychiatric patients in the affected areas, efforts for early detection and intervention of depression, severe stress disorder, adaptation disorder, and alcohol abuse which are expected to occur due to the earthquake and radiation pollution, prevention of suicides, relief from anxiety resulting from radiation pollution, adequate treatment of mental problems among children with long-term evacuation, prevention of fall in physical and mental.

Estimation of marine source-term following Fukushima Dai -ichi accident. Contamination of the marine environment following the accident in the Fukushima Dai -ichi nuclear power plant represented the most important artificial radioactive release flux into the sea ever known. The radioactive marine pollution came from atmospheric fallout onto the ocean, direct release of contaminated water from the plant and transport of radioactive pollution from leaching through contaminated soil.

In the immediate vicinity of the plant less than m , the seawater concentrations reached 68 Bq. Due to the accidental context of the releases, it is difficult to estimate the total amount of radionuclides introduced into seawater from data obtained in the plant. An evaluation is proposed here, based on measurements performed in seawater for monitoring purposes.

Quantities of Cs in seawater in a km area around the plant were calculated from interpolation of seawater measurements. The environmental halftime of seawater in this area is deduced from the time-evolution of these quantities. This halftime appeared constant at about 7 days for Cs. These data allowed estimation of the amount of principal marine inputs and their evolution in time: a total of 27 PBq 12 PBq—41 PBq of Cs was estimated up to July Even though this main release may be followed by residual inputs from the plant, river runoff and leakage from deposited sediments, it represents the principal source-term that must be accounted for future studies of the consequences of the accident on marine systems.

This work had as objective to evaluate the conformity of agricultural tractors workplaces accesses and exits made in Brazil. Among the parameters evaluated, the platform weight of operator workplace was attended by all the tractors. The items in less conformoty in agricultural tractors are the doorpost of protection on the steps and the handrail to the operator.

The tractors with more powerful engines. Preliminary health cancer risk assessment for arsenic exposure in a contaminated area close to a fertilizer plant in Moscow region Russia ; Valutazione preliminare del rischio sanitario cancerogeno per esposizione ad arsenico in un'area contaminata da un'industria di fertilizzanti nella regione di Mosca Russia.

Zakharova, T. Facolta' di Scienze Ambientali. At present, fertilizer plants are considered as one of the main sources of potentially contaminated areas in Russia. In this paper, an interesting experimental case-study area located in Moscow Region has been considered for the preliminary health cancer risk assessment for arsenic exposure. Arsenic has been selected as the individual contaminant indicator, according to a specific, original selection procedure presented in the paper.

For estimating the human exposure to arsenic through multiple pathways, the original McKone and Daniels 91 model has been used. As a result of this preliminary assessment step for the case-study area, the calculated individual cancer risk levels for arsenic exposure through in risk ranking order consumption of agricultural products - consumption of drinking water - dermal contact - direct soil ingestion - ingestion of dairy products are significant. The present paper could be assumed too as a contribution for comparison and stimulus to the actual, Italian situation of soil quality criteria, especially regarding the agricultural land use.

Nel presente lavoro, viene affrontato un interessante caso sperimentale di studio localizzato nella Regione di Mosca, per il quale viene condotta la valutazione preliminare del rischio sanitario cancerogeno per esposizione ad arsenico contaminante selezionato come indicatore, mediante apposita procedura descritta nel lavoro. Allo scopo, e' stato implementato l'originale modello multiplo di valutazione dell'esposizione umana cosiddetto McKone and Daniels Per l'area in studio, i livelli massimi possibili risultanti di rischio cancerogeno per l'arsenico connessi alle vie di migrazione nell'ordine ingestione di prodotti agricoli - assunzione di acqua di falda - contatto dermico.

Kampo medicine " Dai -kenchu-to" prevents CPTinduced small-intestinal injury in rats. The key anticancer agent, CPT irinotecan hydrochloride , induces severe diarrhea clinically. The rats were killed on day 6. Influence of Dai -kenchu-to DKT on human portal blood flow. Dai -kenchu-to DKT is known as an herbal medicine used for postoperative ileus.

However, no report exists about the effect of DKT on portal blood flow. The aim of this study is to clarify the influence of DKT on portal blood flow. Furthermore, the arterial blood pressure and heart rate was measured at the same time points. However, there was no change in average blood pressure and heart rate in all groups. DKT increases portal blood flow in early phase after oral administration without any significant changes in the blood pressure and heart rate. Effect of Dai -kenchu-to on gastrointestinal motility and gastric emptying. The gastrointestinal symptoms accompanying dysfunction of the remnant stomach were seen after pylorus-preserving operation.

Against such complications, Dai -kenchu-to DKT is used, but scientific evidences for efficacy are poor. The effect of DKT on gastrointestinal motility and gastric emptying after pylorus-preserving operation was investigated. Using beagle dogs, the experimental models mimicking the state after pylorus-preserving pancreaticoduodenectomy were prepared.

We sutured strain gauge transducers to the stomach, duodenum and jejunum and inserted indwelling tubes into the stomach. About 4 weeks after operation, DKT 0. At the same time, the gastric emptying was evaluated by the acetoaminophene method. In the fasting state, administration of DKT enhanced the gastrointestinal motility and accelerated gastric emptying.

In the postprandial state, no apparent effect on motility was seen. DKT enhances the gastrointestinal motility after pylorus-preserving pancreaticoduodenectomy in the fasting state. The effect of DKT may not be related to the continuity of the intramural nerve.

Atmospheric radionuclides from the Fukushima Dai -ichi nuclear reactor accident observed in Vietnam. Peaks of radionuclide concentrations in the air corresponded to arrival of the air mass from Fukushima to Vietnam after traveling for 8 days over the Pacific Ocean. The ratio at Dalat, where is m high, was higher than those at Hanoi and HCMC in low lands, indicating the relative enrichment of the iodine in comparison to cesium at high altitudes. The time-integrated surface air concentrations of the Fukushima-derived radionuclides in the Southeast Asia showed exponential decrease with distance from Fukushima.

Atmospheric radionuclides from Fukushima Dai -ichi nuclear accident detected in Lanzhou, China. After the Fukushima Dai -ichi nuclear power plant accident on March 11, , the radioactivity released from the accident was transported around the globe by atmospheric processes. The radioactivity monitoring program on atmospheric particulate in Lanzhou, China was activated by GSCDC to detect the input radionu-clides through atmospheric transport.

Several artificial radionuclides were detected and measured in aerosol samples from March 26 to May 2, The significant increase of Cs activity concentration, one order of magnitude higher than pre-Fukushima accident levels, in ground level aerosol was observed in , as its re-suspension from soil. The value of effective dose for inhalation is close to one millionth of the annual limit for the general public.

This report comments the evolution of radioactive deposits and of produce contamination around the Fukushima Dai -Ichi power plant residual radioactive wastes, contamination of products produced in Japan , indicates and comments the prescriptions and recommendations made by Japanese authorities for marketing and commercialization of foodstuffs, for life in contaminated areas , gives recommendations to French nationals going to or living in Japan in the most impacted areas.

Appendixes contained more detailed presentations and comments on the evolution of radioactive deposits and of the implemented zoning around the power plant, on the exposure of population to gamma radiation emitted by radioactive deposits and on the evolution of evacuated areas, on the evolution of the contamination of products produced in Japan and on risks for consumers maps or graphs illustrate the present situation and the evolution since and , and also report measurements performed by the IRSN on a route in the city of Fukushima location on the map of radioactive deposits in Japan, overview of the followed route and dose rate at the starting point, observations in the urban part of the route and on the wooded hill, dose received by external exposure during a mission in Fukushima.

Situation of Fukushima Dai -ichi power plant in Japan - June 1, status; Situation de la centrale nucleaire de Fukushima Dai -ichi au Japon - Point de situation du 1er juin Situation of Fukushima Dai -ichi power plant in Japan - May 25, status; Situation de la centrale nucleaire de Fukushima Dai -ichi au Japon - Point de situation du 25 mai Fattore umano e rischio sistemico: un memento.

Indeed, looking back over the last years it is hard not to get a sense of their regularity or invincible fate. The author offers some semantic and theoretical premises before looking into the role of the human factor in the prevention and control of a crisis from spreading from an isolated case to the system as a whole. Cases are described in which organisational consistency and the quality of corporate governance, shared purposes and a common culture, and sufficient transparency are important to containing systemic risk and curbing panics.

Rischio ed emergenze sociali: la raccolta rifiuti. Although the emergency involves the implementation of specific interventions, which require the contribution of specialistic abilities, it is important to remember the systemic nature of risk presence and to develop an integrated and interdisciplinary work capacity.

No increase in the portal blood flow in the cirrhotic liver rats was probably the result of the cirrhotic liver, which had fibrotic change, and, therefore, may not have had sufficient compliance to accept the increasing blood flow volume from the intestinal tract. We suggested DKT has the potential to protect the liver by increasing PBF when the liver has either normal or mild to moderate dysfunction.

Dai -kenchu-to DKT , a traditional Japanese herbal medicine, is known to increase gastrointestinal motility and improve ileal function. Visceromotor responses were analyzed using electromyography in response to colorectal distention 10, 20, 40, 60, and 80 mmHg for 20 seconds at 3-minutes intervals. Anxiety-related behavior was measured during exposure to an elevated-plus maze after colorectal distention.

Plasma ACTH and serum corticosterone levels were measured after exposure to the elevated-plus maze. Colorectal distention produced robust contractions of the abdominal musculature, graded according to stimulus intensity, in vehicle-treated rats. At 40, 60, and 80 mmHg of colorectal distention, the visceromotor responses of DKT-treated rats was significantly lower than that of vehicle-treated rats. At 80 mmHg, the amplitude was suppressed to approximately one-third in DKT-treated rats, compared with that in vehicle-treated rats.

Smooth muscle compliance and the velocity of accommodation to 60 mmHg of stretching did not significantly differ between the vehicle-treated and DKT-treated rats. Similarly, the DKT did not influence colorectal distention-induced ACTH release, corticosterone levels, or anxiety-related behavior in rats. Our results suggest that DKT attenuates the colorectal distention-induced visceromotor responses, without increasing smooth muscle compliance, ACTH release or anxiety-related behavior in rats.

The total release of xenon from the Fukushima Dai -ichi nuclear power plant accident. We determine the total emission of the noble gas xenon Xe using global atmospheric concentration measurements. For estimating the emissions, we used three different methods: i using a purely observation-based multi-box model, ii comparisons of dispersion model results driven with GFS meteorological data with the observation data, and iii such comparisons with the dispersion model driven by ECMWF data.

Two of our three methods indicate even higher emissions, but this may not be a robust finding given the differences between our estimates. In DKT group, rats were ad Radiocarbon 14C has been measured in single tree ring samples collected from the southwest of the Fukushima Dai -ichi Nuclear Power Plant.